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RECORD NUMBER: 5 OF 964

OLS Field Name OLS Field Data
Main Title 1-Chloromethylpyrene: A Reference Skin Sensitizer and Genotoxin.
Author Ashby, J. ; Gallagher, J. E. ; Kohan, M. ; Tinwell, H. ; Kimber., I. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Institut de Recherches Scientifiques sur le Cancer, Villejuif (France). ;Imperial Chemical Industries Ltd., Alderley Park (England). Central Toxicology Lab.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/174;
Stock Number PB91-115782
Additional Subjects Toxicology ; Mutagens ; Skin(Anatomy) ; Sensitizing ; Deoxyribonucleic acids ; Carcinogens ; Salmonella typhimurium ; Deoxyribonucleic acids ; Mice ; Lymph nodes ; Bone marrow ; Reprints ; 1-chloromethylpyrene ; Mutagenicity tests ; Micronucleus test ; Benzo(a)pyrene ; Biotransformation ; Contact dermatitis
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB91-115782 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/04/1991
Collation 10p
Abstract 1-Chloromethylpyrene has been evaluated as a model mutagen and toxin related to the ultimate electrophiles derived from BaP and 1-nitropyren. It was mutagenic to Salmonella (>100 picograms/plate) and exceptionally reactive to DNA when assessed by the postlabeling assay. 1-CMP was inactive in a mouse bone marrow micronucleus assay when administered by gavage probably due to hydroylis whose kinetics have been studied (half life 23 min at 37 C). However as expected it was a potent skin toxin as determined by its activity as a mitogen to mouse skin and its contact allergenicity, as determined using the local lymph node proliferative assay. It is concluded that 1-CMP will probably be a potent human skin carcinogen and contact allergen. (Copyright (c) 1990 Elsevier Science Publishers B.V. (Biomedical Division).)
Supplementary Notes Pub. in Mutation Research, v243 n4 p281-289 Apr 90. Prepared in cooperation with Institut de Recherches Scientifiques sur le Cancer, Villejuif (France), and Imperial Chemical Industries Ltd., Alderley Park (England). Central Toxicology Lab.
NTIS Title Notes Journal article.
Title Annotations Reprint: 1-Chloromethylpyrene: A Reference Skin Sensitizer and Genotoxin.
Category Codes 57Y; 57F
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 036522833
Origin NTIS
Type CAT