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OLS Field Name OLS Field Data
Main Title Effects of Water Pollutants and Other Chemicals on Fish Acetylcholinesterase (In vitro).
Author Olson, D. L. ; Christensen, G. M. ;
CORP Author Environmental Research Lab.-Duluth, MN.
Year Published 1979
Report Number EPA-600/J-80-340;
Stock Number PB82-127440
Additional Subjects Acetylcholinesterase ; Water pollution ; Fishes ; Contaminants ; Inhibitors ; Enzymes ; Reprints ; Fathead minnows ; Pimephales promelas ; Water pollution effects(Animals)
Library Call Number Additional Info Location Last
NTIS  PB82-127440 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 11p
Abstract Acetylcholinesterase (AChE) preparations from the muscle of the fathead minnow (Pimephales promelas Rafinesque) were treated (in vitro) with 74 chemicals of various classes, many of which are environmental contaminants, to determine their effect upon enzyme activity. A highly inhibitory effect was found with several carbamates, one organo-oxy-phosphate, the arsenite ion, and certain heavy metal cations. Intermediate inhibition was found with the arsenate ion, other metal cations, organometals, certain neuroactive agents, organophosphates, and one organochloride pesticide. Several organochloride pesticides, alkaline and alkaline-earth cations, a variety of anions, several drugs, and other chemicals had little inhibitory effect at the highest concentration used (0.01 M). The effect of chemicals in mixtures of known composition was approximately additive. None of the chemicals tested caused detectable enzyme activation.
Supplementary Notes Pub. in Environmental Research 21, p327-335 1980.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effects of Water Pollutants and Other Chemicals on Fish Acetylcholinesterase (In vitro).
PUB Date Free Form 10 Apr 79
Category Codes 6T; 6F; 57Y; 68D
NTIS Prices PC A02/MF A01
Primary Description 600/03
Document Type NT
Cataloging Source NTIS/MT
Control Number 323807671
Origin NTIS
Type CAT