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OLS Field Name OLS Field Data
Main Title Effects of NGF and Fetal Cell Transplants on Spatial Learning after Intradentate Administration of Colchicine.
Author Barone, S. ; Tandon, P. ; McGinty, J. F. ; Tilson, H. A. ;
CORP Author Environmental Protection Agency, Research Triangle Park, NC. Neurotoxicology Div. ;East Carolina Univ. School of Medicine, Greenville, NC.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-92/063;
Stock Number PB92-150770
Additional Subjects Colchicine ; Nerve growth factors ; Fetal tissue transplantation ; Spatial behavior ; Cerebellar nuclei ; Hippocampus ; Immunohistochemistry ; Acetylcholinesterase ; Enkephalins ; Reprints ;
Holdings
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Checkout
Status
NTIS  PB92-150770 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/28/1992
Collation 15p
Abstract The study was performed to assess the effects of NGF infusion alone or in combination with fetal hippocampal transplants on recovery of function after damage to hippocampal dentate granule cells. Two groups of male Fischer-344 rats received bilateral infusions of colchicine (COLCH; 2.5 microgram/site) or artificial cerebrospinal fluid (ACSF; 0.5 microliter) through chronic indwelling cannulae into the dentate gyrus. At the time of COLCH injection, a unilateral intracerebroventricular (ICV) cannula was implanted. Morphological examination performed after behavioral testing confirmed the presence of viable transplants and COLCH-induced granule cell loss. These data demonstrate a time-dependent facilitative effect of exogenously applied NGF on functional deficiencies produced by experimentally induced neurodegeneration in the dentate gyrus of the hippocampus.
Supplementary Notes Pub. in Experimental Neurology, v114 n3 p351-363, 1 Dec 91. See also PB91-211508. Prepared in cooperation with East Carolina Univ. School of Medicine, Greenville, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effects of NGF and Fetal Cell Transplants on Spatial Learning after Intradentate Administration of Colchicine.
Category Codes 57Q; 57X; 57T
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 211522903
Origin NTIS
Type CAT