| Main Title |
Support: Letter from CIBA-GEIGY Corp. to USEPA re: (R)-2-(((1 Methylethylidene)Amino)Oxy)Ethyl 2-(4-((6-Chloro- 2-Quinoxalinyl) Oxy)Phenoxy)Propanoate, dated 05/19/1994. |
| CORP Author |
CIBA-GEIGY Corp., Ardsley, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1994 |
| Report Number |
8EHQ-0594-1146 |
| Stock Number |
OTS0530360-2 |
| Additional Subjects |
Toxicology ;
Health effects ;
(R)-2-(((1 methylethylidene)amino)oxy)ethyl 2-(4-((6-chloro- 2-quinoxalinyl) oxy)phenoxy)propanoate ;
Chronic toxicity ;
Carcinogencity ;
Mammals ;
Mice ;
Oral ;
Rats ;
CAS No 111479-05-1
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0530360-2 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
The results of the completed study corroborated the preliminary findings, indicating an increased incidence of hepatocellular adenomas at the two highest doses in males and at the highest dose in females, and an increased incidence of hepatocellular carcinomas at the two highest doses for both males and females. In addition, there was an increased incidence of Leydig-cell tumors in the testes of high-dose males. Treatment-related increases in non- neoplastic lesions were also found, primarily at the two highest doses, including hyperplasia and hypertrophy in the liver, degenerative vascular and tubular changes in the papillary region of the kidney, colloid changes in the thyroid, alveolar macrophage accumulation, Leydig-cell hyperplasia and tubular atrophy and aspermia in the testes, and chronic degenerative myelinopathy of the sciatic nerve. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5301 Shawnee Road, Alexandria, VA, 22312, USA. |
| PUB Date Free Form |
23 May 1994 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
100700190 |
| Origin |
NTIS |
| Type |
CAT |
