Main Title |
Thermoregulation in Mice Following Acute Administration of Lead Acetate. |
Author |
Gordon, C. J. ;
Workman, R. A. ;
Highfill, J. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. |
Year Published |
1987 |
Report Number |
EPA/600/J-87/223; |
Stock Number |
PB88-171087 |
Additional Subjects |
Toxicology ;
Thermoregulation ;
Lead acetate ;
Mice ;
Laboratory animals ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-171087 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
6p |
Abstract |
Several reports in the literature suggest a relationship between lead intoxication and thermoregulatory capacity. To investigate the effects of lead on the control of body temperature, mice of the BALB/c strain were injected intraperitoneally with lead acetate (0 to 100 mg/kg) while colonic temperature was measured 30, 60, and 90 min post-injection at ambient temperatures (Ta) of 20 and 30 C. Lead acetate caused a transient hypothermia, an effect which was augmented at cooler Ta's. In a second experiment, mice were injected with 100 mg/kg lead acetate and placed in a longitudinal temperature gradient to measure their preferred Ta. Lead acetate significantly reduced the preferred Ta during the first 30 min post-injection. Thus, lead acetate-treated mice selected a cooler Ta which augmented the lead-induced hypothermia. In a third experiment it was found that lead acetate-induced lethality was potentiated with increasing Ta. Hence, the hypothermic response to acute lead acetate treatment may be beneficial to survival. |
Supplementary Notes |
Pub. in Neurotoxicology and Teratology, v9 p193-196 1987. See also PB86-175429. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Thermoregulation in Mice Following Acute Administration of Lead Acetate. |
PUB Date Free Form |
c1987 |
Category Codes |
57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
811327569 |
Origin |
NTIS |
Type |
CAT |