Main Title |
Methoxyacetaldehyde, an Intermediate Metabolite of 2-Methoxyethanol, Is Immunosuppressive in the Rat. |
Author |
Smialowicz, R. J. ;
Riddle, M. M. ;
Williams, W. C. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
Publisher |
1993 |
Year Published |
1993 |
Report Number |
EPA/600/J-94/037; |
Stock Number |
PB94-137171 |
Additional Subjects |
Immunosuppressive agents ;
Metabolism ;
Rats ;
Disulfiram ;
Cyanamide ;
Aldehyde dehydrogenase ;
Reprints ;
Acetaldehyde/methoxy ;
Ethanol/2-methoxy
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB94-137171 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
2-Methoxyethanol (ME) is metabolized to 2-methoxyacetic acid (MAA) via the intermediate metabolite methoxyacetaldehyde (MAAD). In this study, the plaque-forming cell (PFC) response to trinitrophenyl-lipopolysaccharide (TNP-LPS) was used to determine if MAAD is immunosuppressive in rats. Rats pretreated with the aldehyde dehydrogenase inhibitors disulfiram or cyanamide followed by oral dosing with ME resulted in suppressed PFC responses equivalent to the suppressed responses of rats dosed with ME alone. Rats pretreated with disulfiram and then dosed with 2.64 mmol/kg 2-methoxyethyl acetate (MEA), also resulted in suppressed PFC responses similar to that of MEA alone. In contrast, coadministration of the alcohol dehydrogenase inhibitor 4-methylpyrazole with ME or MEA blocked suppression of the PFC response following exposure to ME or MEA alone. Oral dosing with equimolar concentrations of ME, MAA, or MAAD resulted in equivalent suppression of the TNP-LPS PFC response. Rats exposed to either disulfiram or cyanamide and MAAD also resulted in suppression of the PFC response. |
Supplementary Notes |
Pub. in Fundamental and Applied Toxicology, v21 n7 p1-7 Jul 93. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Methoxyacetaldehyde, an Intermediate Metabolite of 2-Methoxyethanol, Is Immunosuppressive in the Rat. |
Category Codes |
57Y; 57J; 57S |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
407720006 |
Origin |
NTIS |
Type |
CAT |