||Effects of Chronic Exposure to 2, 3, 7, 8,-Tetrachlorodibenzo-p-Dioxin on Sister Chromatid Exchange Levels in Peripheral Lymphocytes of the Rhesus Monkey.
Lim, M. ;
Jacobson-Kram, D. ;
Bowman, R. E. ;
Williams, J. R. ;
||Johns Hopkins Oncology Center, Baltimore, MD. Radiobiology Lab. ;Wisconsin Univ.-Madison.;Environmental Protection Agency, Washington, DC. Office of Research and Development.
||EPA-R-812535 ;EPA-R-811685; EPA/600/J-87/360;
Hazardous materials ;
Laboratory animals ;
Toxic substances ;
Chronic exposure ;
Chromosome aberrations ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Frequencies of sister chromatid exchanges and chromosomal aberrations were examined in peripheral lymphocytes of Rhesus monkeys that had been fed a diet containing 25 parts per trillion 2,3,7,8-tetrachlorodibenzo-p-dioxin for a period of 4 years. When compared to non-exposed control animals, no significant differences were noted for either of these cytogenetic end points. In addition, there was not a significant difference in sister chromatid exchange response to a challenge dose of mitomycin C in cells from 2,3,7,8-tetrachlorodibenzo-p-dioxin exposed animals compared to controls. The results confirm the lack of genotoxic effects associated with 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure.
||Pub. in Cell Biology and Toxicology, v3 n3 p279-284 1987. Prepared in cooperation with Wisconsin Univ.-Madison. Sponsored by Environmental Protection Agency, Washington, DC. Office of Research and Development.
|NTIS Title Notes
||Reprint: Effects of Chronic Exposure to 2, 3, 7, 8,-Tetrachlorodibenzo-p-Dioxin on Sister Chromatid Exchange Levels in Peripheral Lymphocytes of the Rhesus Monkey.
|PUB Date Free Form
||57Y; 57F; 57Z
||PC A02/MF A01