Main Title |
Will the Mouse Bioassay for Estimating Sensory Irritancy of Airborne Chemicals (ASTM E 981-84) Be Useful for Evaluation of Indoor Air Contaminants. |
Author |
Tepper, J. S. ;
Costa, D. L. ;
|
CORP Author |
ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
Publisher |
cNov 92 |
Year Published |
1992 |
Report Number |
EPA-68-D2-0056; EPA/600/J-94/331; |
Stock Number |
PB94-202124 |
Additional Subjects |
Indoor air pollution ;
Irritants ;
Test methods ;
Bioassay ;
Mice ;
Exposure ;
Risk assessment ;
Laboratory tests ;
Air pollution detection ;
Air pollution effects(Humans) ;
Reprints ;
American Standard Test Method E 981-84 ;
ASTM E 981-84
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB94-202124 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
8p |
Abstract |
For many toxic inhalants, sensory irritation is the first detectable response. A standardization bioassay, ASTM E 981-84, that quantitates irritancy as a reduction in breathing rate of the mouse during inhalation exposure, has been developed. The validation of this screen for detecting irritation is based on the high rank-correlation between 0.03 x RD(50) and the TLVs-TWAs for numerous inhaled chemicals. The screen does not indicate the relative offensiveness of an odor, does not address all pulmonary hazards or non-irritating systemic hazards, and is not a replacement for chronic toxicity testing. Despite the limitations, prudent application of ASTM E 981-84 appears to provide a rapid, inexpensive means to identify indoor atmospheres of irritant potential. |
Supplementary Notes |
Pub. in Indoor Environment 1, n6 p367-372 Nov 92. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
Availability Notes |
Journal article. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Will the Mouse Bioassay for Estimating Sensory Irritancy of Airborne Chemicals (ASTM E 981-84) Be Useful for Evaluation of Indoor Air Contaminants. |
Category Codes |
68A; 68G; 57U |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
427627632 |
Origin |
NTIS |
Type |
CAT |