||Compensatory Tracking in Humans with Elevated Carboxyhemoglobin.
Benignus, V. A. ;
Muller, K. E. ;
Smith, M. V. ;
Pieper, K. S. ;
Prah, J. D. ;
||Health Effects Research Lab., Research Triangle Park, NC. Clinical Research Branch. ;North Carolina Univ. at Chapel Hill.
Carbon monoxide ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||A total of seventy-four men divided into five groups performed a compensatory tracking task for 4 hr with group mean carboxyhemoglobin (COHb) levels of 0.9, 5.6, 6.1, 11.4 or 16.6%. In all but one group, COHb was formed in approximately 5 min by having the subject breathe a high concentration of carbon monoxide (CO) from a Douglas bag. An appropriate low level of CO in the exposure/test chamber maintained the elevated COHb for the 4 hr duration of the experiment. A slow COHb formation group, not exposed to CO during bag breathing, which was only exposed to low-level CO in the exposure/testing chamber, served as a positive control. Even at the highest dose, the increase in tracking error was small. The increased mean error score due to rapid formation was virtually the same as that due to slow formation.
||Pub. in Neurotoxicology and Teratology, v12 p105-110 Jan 90. Prepared in cooperation with North Carolina Univ. at Chapel Hill.
|NTIS Title Notes
||Reprint: Compensatory Tracking in Humans with Elevated Carboxyhemoglobin.
||57S; 57B; 57Y
||PC A02/MF A01