||Trophic Control of the Ornithine Decarboxylase/Polyamine System in Neonatal Rat Brain Regions: Lesions Caused by 6-Hydroxydopamine Produce Effects Selective for Cerebellum.
Lau, C. ;
Cameron, A. ;
Antolick, L. ;
Slotkin, T. A. ;
||Northrop Services, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Body weight ;
Ornithine decarboxylase ;
Newborn animals ;
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||Norepinephrine has been hypothesized as a trophic factor influencing postnatal development of the cerebellum. In the current study, neonatal rats were given 6-hydroxydopamine (6-OHDA) to destroy noradrenergic projections and the effects on the ornithine decarboxylase (ODC)/polyamine system were evaluated; ODC initiates the synthesis of polyamines, which are known to control cellular development in the cerebellum, and neonatal ODC activity is regulated in part by B2-adrenergic receptors. Intracisternal administration of 6-OHDA resulted in complete and permanent depletion of cerebellar norepinephrine and a deficit in ODC, polyamine levels and cerebellar growth. Subcutaneous administration of 6-OHDA, which caused only a small initial reduction in cerebellar norepinephrine, did not affect ODC and had only minor effects on tissue growth. Indeed, levels of the polyamines tended to be elevated after subcutaneous 6-OHDA, associated with postweaning elevations in norepinephrine, results which are probably indicative of axonal regeneration. (Copyright (c) 1990 Elsevier Publishers BV (Biomedical Division).)
||Pub. in Developmental Brain Research, v52 p167-173 Jan 90. Prepared in cooperation with Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Trophic Control of the Ornithine Decarboxylase/Polyamine System in Neonatal Rat Brain Regions: Lesions Caused by 6-Hydroxydopamine Produce Effects Selective for Cerebellum.
||PC A02/MF A01