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OLS Field Name OLS Field Data
Main Title Trophic Control of the Ornithine Decarboxylase/Polyamine System in Neonatal Rat Brain Regions: Lesions Caused by 6-Hydroxydopamine Produce Effects Selective for Cerebellum.
Author Lau, C. ; Cameron, A. ; Antolick, L. ; Slotkin, T. A. ;
CORP Author Northrop Services, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/049;
Stock Number PB90-217464
Additional Subjects Biochemistry ; Polyamines ; Cerebellum ; Graphs(Charts) ; Body weight ; Norepinephrine ; Reprints ; Ornithine decarboxylase ; Hydroxydopamines ; Newborn animals ; Organ weight
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NTIS  PB90-217464 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/27/1990
Collation 9p
Abstract Norepinephrine has been hypothesized as a trophic factor influencing postnatal development of the cerebellum. In the current study, neonatal rats were given 6-hydroxydopamine (6-OHDA) to destroy noradrenergic projections and the effects on the ornithine decarboxylase (ODC)/polyamine system were evaluated; ODC initiates the synthesis of polyamines, which are known to control cellular development in the cerebellum, and neonatal ODC activity is regulated in part by B2-adrenergic receptors. Intracisternal administration of 6-OHDA resulted in complete and permanent depletion of cerebellar norepinephrine and a deficit in ODC, polyamine levels and cerebellar growth. Subcutaneous administration of 6-OHDA, which caused only a small initial reduction in cerebellar norepinephrine, did not affect ODC and had only minor effects on tissue growth. Indeed, levels of the polyamines tended to be elevated after subcutaneous 6-OHDA, associated with postweaning elevations in norepinephrine, results which are probably indicative of axonal regeneration. (Copyright (c) 1990 Elsevier Publishers BV (Biomedical Division).)
Supplementary Notes Pub. in Developmental Brain Research, v52 p167-173 Jan 90. Prepared in cooperation with Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Trophic Control of the Ornithine Decarboxylase/Polyamine System in Neonatal Rat Brain Regions: Lesions Caused by 6-Hydroxydopamine Produce Effects Selective for Cerebellum.
Category Codes 57B; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 019411147
Origin NTIS
Type CAT