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RECORD NUMBER: 8 OF 14

OLS Field Name OLS Field Data
Main Title Lack of Initiating and/or Promoting Activity of Sodium Malondialdehyde on Sencar Mouse Skin.
Author Fischer, S. M. ; Ogle, S. ; Marnett, L. J. ; Nesnow, S. ; Slaga, T. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Experimental Biology Div. ;Oak Ridge National Lab., TN. ;Wayne State Univ., Detroit, MI. Dept. of Chemistry.
Year Published 1983
Report Number EPA-600/J-83-166;
Stock Number PB84-170968
Additional Subjects Toxicology ; Mutagens ; Mice ; Skin(Anatomy) ; Reprints ; Carcinogenesis ; Malondialdehyde
Holdings
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NTIS  PB84-170968 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 8p
Abstract Malondialdehyde (MDA), a lipid peroxidation product, has been implicated in carcinogenesis in part for its reported mutagenic activity. It was of interest therefore, to determine its activity as either a complete carcinogen, a tumor initiator, or a tumor promoter. Using the SENCAR mouse skin model, pure sodium MDA (NaMDA) was found to lack activity in any of these categories. Furthermore, NaMDA was determined to be negative in the Chinese hamster V-79 metabolic cooperation assay for promoters.
Supplementary Notes Prepared in cooperation with Oak Ridge National Lab., TN. and Wayne State Univ., Detroit, MI. Dept. of Chemistry.
Availability Notes Pub. in Cancer Letters, v19 p61-66 1983.
NTIS Title Notes Journal article.
Title Annotations Reprint: Lack of Initiating and/or Promoting Activity of Sodium Malondialdehyde on Sencar Mouse Skin.
PUB Date Free Form c1983
Category Codes 6T; 6E; 57Y; 57O
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 417424451
Origin NTIS
Type CAT