||Lack of Initiating and/or Promoting Activity of Sodium Malondialdehyde on Sencar Mouse Skin.
Fischer, S. M. ;
Ogle, S. ;
Marnett, L. J. ;
Nesnow, S. ;
Slaga, T. J. ;
||Health Effects Research Lab., Research Triangle Park, NC. Experimental Biology Div. ;Oak Ridge National Lab., TN. ;Wayne State Univ., Detroit, MI. Dept. of Chemistry.
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Malondialdehyde (MDA), a lipid peroxidation product, has been implicated in carcinogenesis in part for its reported mutagenic activity. It was of interest therefore, to determine its activity as either a complete carcinogen, a tumor initiator, or a tumor promoter. Using the SENCAR mouse skin model, pure sodium MDA (NaMDA) was found to lack activity in any of these categories. Furthermore, NaMDA was determined to be negative in the Chinese hamster V-79 metabolic cooperation assay for promoters.
||Prepared in cooperation with Oak Ridge National Lab., TN. and Wayne State Univ., Detroit, MI. Dept. of Chemistry.
||Pub. in Cancer Letters, v19 p61-66 1983.
|NTIS Title Notes
||Reprint: Lack of Initiating and/or Promoting Activity of Sodium Malondialdehyde on Sencar Mouse Skin.
|PUB Date Free Form
||6T; 6E; 57Y; 57O
||Not available NTIS