||Mouse Skin Tumor-Initiating Activity of Benz(j)aceanthrylene in SENCAR Mice.
Nesnow, S. ;
Gold, A. ;
Sangaiah, R. ;
Slaga, T. J. ;
||Health Effects Research Lab., Research Triangle Park, NC. Carcinogenesis and Metabolism Branch. ;North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering. ;Texas Univ. System Cancer Center, Smithville.;Public Health Service, Rockville, MD.
Skin neoplasms ;
Dose-response relationships ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Benz(j)aceanthrylene (B(j)A), a cyclopenta-fused derivative of benz(a)anthracene, has been reported to be an active bacterial cell and mammalian cell gene mutagen, a morphological transforming agent in C3H10T1/2CL8 mouse embryo fibroblasts and a mouse lung tumorigen in strain A/J mice. B(j)A was evaluated as a skin tumor initiator in female SENCAR mice and was found to induce papilloma formation in the range of 40-400 micrograms/mouse. B(j)A was found to be extremely active, inducing 8.7 papillomas/mouse after an initiating dose of 40 micrograms/mouse. At this dose, 100% of the mice bore tumors. Comparison with four other cyclopenta-fused polycyclic aromatic hydrocarbons suggests that B(j)A is extremely potent. (Copyright (c) 1993 Elsevier Scientific Publishers Ireland Ltd.)
||Pub. in Cancer Letters, v73 n2 p73-76 Oct 93. Prepared in cooperation with North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering, and Texas Univ. System Cancer Center, Smithville. Sponsored by Public Health Service, Rockville, MD.
|NTIS Title Notes
||Reprint: Mouse Skin Tumor-Initiating Activity of Benz(j)aceanthrylene in SENCAR Mice.
||PC A02/MF A01