||Mouse Skin Tumor-Initiating Activity of Benz(e)aceanthrylene and Benz(l)aceanthrylene in Sencar Mice.
Nesnow, S. ;
Gold, A. ;
Sangaiah, R. ;
Triplett, L. L. ;
Slaga, T. J. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering. ;Oak Ridge National Lab., TN. Biology Div.
Environmental surveys ;
Aromatic polycyclic hydrocarbons ;
Laboratory animals ;
Public health ;
Skin cancer ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Benz(e)aceanthrylene and benz(1)aceanthrylene, cyclopenta-fused derivatives of benz(1)anthracene, have been reported to be active bacterial cell and mammalian cell gene mutagens. In this study they were evaluated as skin tumor initiators in both male and female SENCAR mice. Both PAH induced papilloma formation in the range of 50-1000 nmol/mouse. Benz(1)aceanthrylene was the most active, being approximately 4 times as activeas benzo(a)pyrene while benz(e)aceanthrylene had activity approximately equivalent to benzo(a)pyrene. These results are in contrast to those reported for the air pollutant, cyclopenta(cd)pyrene, another cyclopenta-fused PAH, which is a weak mouse skin tumor initiator. The authors postulate that these cyclopenta-PAH are formed by pyrosynthetic routes similar to other environmental cyclopenta-PAH and that they may be of importance as contributors to air pollution carcinogenesis. (Copyright (c) 1984 Elsevier Scientific Publishers Ireland Ltd.)
||Prepared in cooperation with North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering, and Oak Ridge National Lab., TN. Biology Div.
||Pub. in Cancer Letters 22, p263-268 1984.
|NTIS Title Notes
||Reprint: Mouse Skin Tumor-Initiating Activity of Benz(e)Aceanthrylene and Benz(l)Aceanthrylene in Sencar Mice.
|PUB Date Free Form
||6T; 6E; 68G; 57U; 57Y
||Not available NTIS