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OLS Field Name OLS Field Data
Main Title Pulmonary Effects Due to Short-Term Exposure to Oil Fog.
Author Selgrade, M. K. ; Hatch, G. E. ; Grose, E. C. ; Illing, J. W. ; Snead, A. G. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Durham, NC. Inhalation Toxicology Group. ;Experimental Pathology Associates, Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/J-87/094;
Stock Number PB88-139639
Additional Subjects Toxicology ; Respiratory system ; Exposure ; Rats ; Laboratory animals ; Vaporization ; Histopathology ; Reprints ; Air pollution effects ; Oil fog
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NTIS  PB88-139639 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 15p
Abstract Rats were exposed to an oil fog generated by flash vaporization and subsequent condensation of light weight lubricating oil. Exposures were for 3.5 hrs/day, 4 days/wk, for 4 wks, at concentrations of 1.5, 0.5, or 0.1mg/1 and a particle size of approximately 1 micronole. Samples of respiratory tissues were taken for histopathologic analyses, lavage fluid samples were collected, and pulmonary function measurements were made the day after the last exposure. An accumulation of macrophages within the alveolar lumen, an increase in lavage fluid protein content, and an increase in total cell content in lavage fluid due to an influx of polymorphonuclear leukocytes was noted in rats exposed at the 1.5 mg level. Also, for the exposure group there was an increase in lung wet and dry weight, and an increase in end expiratory volume, and pneumonitis was observed histopathologically in 4 of 10 male rats exposed. Pneumonitis was not observed among 6 female rats examined. Oil fog had no effect on total lung capacity, residual volume, vital capacity, lung compliance, or the distribution of ventilated air within the lung. Effects following exposure to 0.5 mg/1 were limited to slight accumulation of macrophages in the alveolar lumen and an increase in the total cells in lavage fluid which could not be attributed to an increase in any particular cell type.
Supplementary Notes Pub. in Jnl. of Toxicology and Environmental Health, v21 p173-185 1987. Prepared in cooperation with Northrop Services, Inc., Durham, NC. Inhalation Toxicology Group, and Experimental Pathology Associates, Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Pulmonary Effects Due to Short-Term Exposure to Oil Fog.
PUB Date Free Form c1987
Category Codes 57Y; 68A
NTIS Prices PC A03/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 805623740
Origin NTIS
Type CAT