||Increased Susceptibility to Pentobarbital Following Mouse Cytomegalovirus Infection: Relative Roles of Viral-Induced Interferon and Viral Infection of the Liver.
Catignani, J. C. ;
Menache, M. G. ;
Selgrade, M. K. ;
||Health Effects Research Lab., Research Triangle Park, NC. Inhalation Toxicology Div. ;North Carolina Univ. at Chapel Hill. School of Public Health. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.
Liver diseases ;
Enzyme inhibitors ;
Cytomegalic inclusion disease ;
Disease susceptibility ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The purpose of the study was to determine the relative roles of viral-induced interferon (IFN) and viral infection of the liver in mouse cytomegalovirus (MCMV)-induced depression of cytochrome P-450 (cyt P-450) levels and enhancement of pentobarbital-induced sleeping time (PEN-ST). This was done by establishing the temporal relationship among the IFN response, viral infection of the liver, suppression of cyt P-450 levels, and enhancement of PEN-ST, by determining the effect of anti-IFN antibody treatment on all of these responses, and by manipulating factors known to influence viral pathogenesis and host response to virus such as animal age, virulence of the virus, and dose of virus. (Copyright (c) 1989 VCH Publishers, Inc.)
||Pub. in Jnl. of Biochem Toxicology, v4 n4 p221-228 1989. Prepared in cooperation with North Carolina Univ. at Chapel Hill. School of Public Health, and Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Increased Susceptibility to Pentobarbital Following Mouse Cytomegalovirus Infection: Relative Roles of Viral-Induced Interferon and Viral Infection of the Liver.
||PC A03/MF A01