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OLS Field Name OLS Field Data
Main Title 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Induced Astrogliosis Does Not Require Activation of Ornithine Decarboxylase.
Author O'Callaghan, J. P. ; Seidler, F. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-94/389;
Stock Number PB95-126496
Additional Subjects Astrocytes ; Gliosis ; Ornithine decarboxylase ; Enzyme activation ; Glial fibrillary acidic protein ; Polyamines ; Biosynthesis ; Blood-brain barrier ; Corpus striatum ; Hippocampus ; Reprints ; Pyridine/1-methyl-4-phenyl-1-2-3-6-tetrahydro
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NTIS  PB95-126496 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/06/1995
Collation 8p
Abstract Mechanical injury to the brain results is enhanced immunostaining for glial fibrillary acidic protein (GFAP) that is markedly inhibited by diffuoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxlase. In the current study, systemic exposure of mice to the dopaminergic neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), also increased GFAP but, unlike mechanical injury, this increase was not prevented by DFMO pretreatment. These results indicate that de novo polyamine biosynthesis is not obligatory for the MPTP-induced increase in GFAP. MPTP administration, unlike mechanical injury, does not disrupt the blood-brain barrier; thus, a role for polyamine biosynthesis in the astrocyte response to injury may be restricted to insults involving a compromised blood-brain barrier.
Supplementary Notes Pub. in Neuroscience Letters 148, n1 and 2 p105-108, 14 Dec 92. See also PB91-145045. Prepared in cooperation with Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.
NTIS Title Notes Journal article.
Title Annotations Reprint: 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Induced Astrogliosis Does Not Require Activation of Ornithine Decarboxylase.
Category Codes 57Y; 57F
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 433519196
Origin NTIS
Type CAT