Main Title |
Chloroform Induction of Ornithine Decarboxylase Antizyme (ODC-AZ) in Male Rat Liver (Journal Version). |
Author |
Savage, R. E. ;
Pereira, M. A. ;
DeAngelo, A. B. ;
|
CORP Author |
Health Effects Research Lab., Cincinnati, OH. ;Environmental Health Research and Testing, Inc., Cincinnati, OH. ;National Inst. for Occupational Safety and Health, Cincinnati, OH. |
Publisher |
c1988 |
Year Published |
1988 |
Report Number |
EPA/600/J-88/220; |
Stock Number |
PB89-144539 |
Additional Subjects |
Chloroform ;
Enzyme inhibitors ;
Toxicity ;
Hazardous materials ;
Chlorohydrocarbons ;
Rats ;
Liver ;
Alphaamino carboxylic acids ;
Valeric acid ;
Induction ;
Exposure ;
Laboratory animals ;
Stimulation ;
Reprints ;
Ornithine decarboxylase antizyme ;
Toxic substances
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-144539 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
Chloroform stimulation of rat hepatic ornithine decarboxylase (ODC) is most dramatic at 18 h following a single injection. Repeated dosing, 1 dose/d for up to 7 d, results in a daily decline in the ability of the liver enzyme to respond 18 h after the final injection. This decline was probably due to an increased synthesis and accumulation of the ODC-antizyme (AZ) protein. ODC-AZ was determined by measuring the inhibition of isolated ODC activity. Rats were injected daily for 1, 3, or 7 d with 3.0 mmol/kg chloroform. Chloroform induced ODC-AZ activity in males at 3 and 7 d (26% and 37% inhibition of the ODC activity in the incubation medium, respectively). While females exhibited a similar decline in ODC activity after repeated doses, ODC-AZ was not induced. Thus, it would appear that daily exposure of rats to chloroform results in a refractoriness of its induction of ODC activity accompanied by an induction of the ODC-AZ in males. However, in females these two responses were not directly related. (Copyright (c) 1988 Hemisphere Publishing Corp.) |
Supplementary Notes |
Pub. in Jnl. of Toxicology and Environmental Health, v25 n1 p97-101 Aug 88. See also PB83-189050. Prepared in cooperation with Environmental Health Research and Testing, Inc., Cincinnati, OH., and National Inst. for Occupational Safety and Health, Cincinnati, OH. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Chloroform Induction of Ornithine Decarboxylase Antizyme (ODC-AZ) in Male Rat Liver (Journal Version). |
Category Codes |
57Y; 57B; 57U; 68G |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
908927709 |
Origin |
NTIS |
Type |
CAT |