||Morphometric Aspects of Ciliary Distribution and Ciliogenesis in Human Nasal Epithelium.
Carson, J. L. ;
Collier, A. M. ;
Knowles, M. R. ;
Boucher, R. C. ;
Rose, J. G. ;
||North Carolina Univ., Chapel Hill.;Health Effects Research Lab., Research Triangle Park, NC.
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Observations of freeze-fracture preparations of human nasal epithelium have provided a unique perspective of the spatial distribution of epithelial cell cilia unattainable by more conventional ultrastructural techniques. The initial stages of ciliogenesis were characterized ultrastructurally in these preparations by differentiation of the lumenal aspect of the epithelial cell membrane prior to the emergence and maturation of new cilia. Morphometric analyses of the resultant electron micrographs indicate that the development of an optimal ciliary population during differentiation of ciliated cells may be integral to the adequate functioning of respiratory mucociliary mechanisms. The frequency with which such ciliogenic structures are observed indicates that ciliogenesis is a common feature of the nasal epithelium and suggests that epithelial cell turnover in the nasal cavities is relatively rapid.
||Pub. in Proceedings of the National Academy of Sciences of the United States of America, v78 n11 p6996-6999 Nov 81. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
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||PC A02/MF A01