Full Record Display for the EPA National Library Catalog

RECORD NUMBER: 40 OF 73

OLS Field Name OLS Field Data
Main Title Evaluation of Mutagenic and Carcinogenic Properties of Brominated and Chlorinated Acetonitriles: By-Products of Chlorination.
Author Bull, R. J. ; Meier, J. R. ; Robinson, M. ; Ringhand, H. P. ; Laurie, R. D. ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1985
Report Number EPA/600/J-85/355;
Stock Number PB86-175502
Additional Subjects Toxicology ; Chlorination ; Bioassay ; In vitro analysis ; Reprints ; Acetonitriles ; Carcinogenesis ; Mutagenesis
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB86-175502 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 12p
Abstract The present study was undertaken to determine if chlorinated and brominated acetonitriles formed during the chlorination of drinking water possess mutagenic and/or carcinogenic properties. Chloroacetonitrile (CAN), dichloroacetonitrile (DCAN), trichloroacetonitrile (TCAN), bromochloroacetonitrile (BCAN), and dibromoacetonitrile (DBAN) were tested for their ability (1) to produce point mutations in the Salmonella/microsome assay, (2) to induce sister chromatid exchanges (SCE) in Chinese hamster ovary (CHO) cells in vitro, (3) to produce micronuclei in polychromatic erythrocytes in CD-1 mice, and (4) to act as tumor initiators in the skin of Sencar mice. DCAN and BCAN were found to be direct acting mutagens in Salmonella. All five haloacetonitriles induced SCEs in CHO cells in vitro. This activity paralleled the extent of chlorine substitution and was further enhanced in the dihaloacetonitrile series if bromine was substituted for chlorine. None of the haloacetonitriles showed evidence of activity in the mouse micronucleus assay.
Supplementary Notes Pub. in Fundamental and Applied Toxicology 5, n6 p1065-1074 Dec 85.
NTIS Title Notes Journal article.
Title Annotations Reprint: Evaluation of Mutagenic and Carcinogenic Properties of Brominated and Chlorinated Acetonitriles: By-Products of Chlorination.
PUB Date Free Form 1985
Category Codes 6T; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 614222769
Origin NTIS
Type CAT