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OLS Field Name OLS Field Data
Main Title Synaptonemal Complex Damage Induced by Clastogenic and Anti-Mitotic Chemicals: Implications for Non-Disjunction and Aneuploidy (Journal Version).
Author Allen, J. W. ; Gibson, J. B. ; Poorman, P. A. ; Backer, L. C. ; Moses, M. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Duke Univ. Medical Center, Durham, NC. ;Wellcome Research Labs., Research Triangle Park, NC.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/205;
Stock Number PB89-144471
Additional Subjects Mutagens ; Toxicology ; Synopses ; Mice ; Laboratory animals ; Exposure ; Meiosis ; Mitomycins ; Cyclophosphamide ; Colchicine ; Chromosome abnormalities ; Reprints ; Aneuploidy ; Chromosomal translocation ; Genetic effects ; Mitomycin C ; Amsacrine ; Vinblastine sulfate ; Prophase ; Alkylating agents ; Chromosome breakage ; Toxic substances ; Sister chromatid exchanges ; Antimitotic drugs
Holdings
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Status
NTIS  PB89-144471 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/08/1989
Collation 14p
Abstract Mice were treated with mitomycin C, cyclophosphamide, amuscarine, colchicine, or vinblastine sulfate, and meiotic prophase cells analyzed for synaptonemal complex damage. All test agents caused synaptonemal complex breakage and synapsis irregularities, although propensities for inducing specific types of damage at S-phase or prophase stages varied among the chemicals. The data indicate that SC analysis can reveal chemical-specific alterations to meiotic homologue pairing/synapsis which have not generally been recognized, and which theoretically may be implicated in nondisjunction.
Supplementary Notes Pub. in Mutation Research, v201 p313-324 1988. Prepared in cooperation with Duke Univ. Medical Center, Durham, NC., and Wellcome Research Labs., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Synaptonemal Complex Damage Induced by Clastogenic and Anti-Mitotic Chemicals: Implications for Non-Disjunction and Aneuploidy (Journal Version).
Category Codes 57Y; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 908927647
Origin NTIS
Type CAT