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OLS Field Name OLS Field Data
Main Title Short-term bioassays in the analysis of complex environmental mixtures II /
Author Waters, Michael D.
Other Authors
Author Title of a Work
Waters, Michael D.,
Sandhu, Shahbeg S.,
Huisingh, Joellen Lewtas,
Claxton, Larry D.,
Nesnow, Stephen,
Publisher Plenum Press,
Year Published 1981
Report Number EPA 600-9-82-004
OCLC Number 07925767
ISBN 0306408902; 9780306408908
Subjects Environmental toxicology--Congresses. ; Toxicity testing--Congresses. ; Biological assay--Congresses. ; Environmental chemistry--Congresses. ; Carcinogens, Environmental--analysis. ; Environmental Pollutants--analysis.
Additional Subjects Pollution--Toxicology--Congresses ; Toxicity testing--Congresses ; Biological assay--Congresses ; Environmental chemistry--Congresses
Internet Access
Description Access URL
https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=P100S49W.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EJBD ARCHIVE EPA 600-9-82-004 Headquarters Library/Washington,DC 05/14/2019
EKBM  RA566.S95 1980 Research Triangle Park Library/RTP, NC 01/01/1988
ELDM  RA566.S95 1980 NHEERL/MED Library/Duluth,MN 07/10/1992
Collation xv, 524 pages : illustrations ; 26 cm.
Notes "EPA 600-9-82-004." "March 1982." PB82-233172 Includes bibliographical references and index. "Proceedings of the Second Symposium on the Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures, held in Williamsburg, Virginia, March 4-7, 1980"--Title page verso.
Contents Notes Ambient air -- Drinking water and aqueous effluents -- Terrestrial systems -- Mobile sources -- Stationary source -- Hazard assessment. More than one hundred short-term bioassays are now available for detecting the toxicity, mutagenicity, and potential carcinogenicity of chemicals. These bioassays were developed and validated with individual compounds, and their principal application was perceived to be in evaluating the health hazard of such materials. However, man is rarely exposed to single chemicals; his exposure to hazardous chemicals is more commonly a multifactorial phenomenon. Although chemical analysis can be used to detect known hazardous compounds, it would be a staggering and expensive task to analyze large numbers of samples for all known or suspected hazardous constituents. Furthermore, the biological activity of a complex mixture cannot be reliably predicted from knowledge of its components. On the other hand, bioassays alone cannot tell us which components of complex mixtures are responsible for the biological activity detected. Thus, cost effectiveness and technical feasibility dictate stepwise and perhaps iterative application -of both chemical and biological methods in evaluating the health effects of complex environmental mixtures. Through the coupling of reliable biological detection systems with methods of chemical fractionation and analysis, it is frequently possible to isolate the individual chemical species that show biological activity. Initially, complex mixtures may be separated and bioassayed in carefully defined chemical fractions. The results of such short-term screening bioassays then may be used td guide the course of further fractionation and to determine the need for more stringent and comprehensive biological testing -- Provided by the publisher.
Place Published New York
Title Ser Add Ent Environmental science research ; v. 22.
Conference Title Symposium on the Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures
PUB Date Free Form 1981
Series Title Traced Environmental science research ; v. 22
Series Title Untraced Environmental science research ; v. 22
BIB Level m
Document Type BC
Medium unmediated
Content text
Carrier volume
Cataloging Source RDA
LCCN 81017839
Merged OCLC records 8573627; 16540411
OCLC Time Stamp 20190511060238
Language eng
Origin OCLC
Type CAT
OCLC Rec Leader 05584cam 2200805 i 45010