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RECORD NUMBER: 16 OF 34

OLS Field Name OLS Field Data
Main Title Examination of Immune Parameters and Host Resistance Mechanisms in B6C3F1 Mice Following Adult Exposure to 2,3,7,8-Tetrachlorodibenzo-'p'-Dioxin.
Author House, R. V. ; Lauer, L. D. ; Murray, M. J. ; Thomas, P. T. ; Ehrlich, J. P. ;
CORP Author Chemical Industry Inst. of Toxicology, Research Triangle Park, NC. ;IIT Research Inst., Chicago, IL. Life Sciences Research Div.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher c1990
Year Published 1990
Report Number EPA-68-02-4450; EPA/600/J-90/351;
Stock Number PB91-163659
Additional Subjects Immune system ; Tetrachlorodibenzodioxins ; Toxicology ; Antibody formation ; Mice ; IgM ; IgG ; Dose-response relationships ; Macrophage ; Disease susceptibility ; Viral antigens ; Virus diseases ; Listeria monocytogenes ; Reprints ; Viral hemagglutinins
Holdings
Library Call Number Additional Info Location Last
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Checkout
Status
NTIS  PB91-163659 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/13/1991
Collation 15p
Abstract Adult female B6C3F1 mice were given a single IP dose of 0, 0.1, 1.0, or 10.0 micrograms/kg TCDD and examined for immune function and host resistance seven to ten days later. Exposure to TCDD resulted in a significant dose-related decrease in induction of both IgM and IgG antibody-forming cells. The suppression was noted for both T-dependent and T-independent antigens. TCDD at a dosage of 10 micrograms/kg was shown to suppress production of viral hemagglutinin. In contrast, TCDD exposure had no significant effect on natural killer cell function, production of interferon, or various parameters of macrophage function. Host resistance assessment revealed a significant increase in susceptibility to fatal infection with influenza virus, but no significant alteration in susceptibility to infection with the bacterium Listeria monocytogenes. (Copyright (c) 1990 by Hemisphere Publishing Corporation.)
Supplementary Notes Pub. in Jnl. of Toxicology and Environmental Health, v31 n3 p203-215 Nov 90. Prepared in cooperation with IIT Research Inst., Chicago, IL. Life Sciences Research Div. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
NTIS Title Notes Journal article.
Title Annotations Reprint: Examination of Immune Parameters and Host Resistance Mechanisms in B6C3F1 Mice Following Adult Exposure to 2,3,7,8-Tetrachlorodibenzo-'p'-Dioxin.
Category Codes 57Y; 57J; 68G
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 113027475
Origin NTIS
Type CAT