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RECORD NUMBER: 176 OF 271

OLS Field Name OLS Field Data
Main Title Neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Alters Immune Function When Given in Combination with Diethyldithiocarbamate (DDC).
Author Miller, D. B. ; Luebke, R. W. ; Reinhard, J. ; O'Callaghan., J. P. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Wellcome Research Labs., Research Triangle Park, NC.
Publisher 1991
Year Published 1991
Report Number EPA/600/D-91/191;
Stock Number PB91-231092
Additional Subjects Toxicity ; Nervous system ; Diethyldithiocarbamate ; Immune system ; Dose-response relationships ; Drug synergism ; Spleen ; Thymus gland ; Tyrosine hydroxylase ; Organ weight ; Concanavalin A ; Phytohemagglutinins ; Methylphenyltetrahydropyridine
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB91-231092 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 11/26/1991
Collation 7p
Abstract The T-cell suppression induced by the dopaminergic neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can be reversed if treatment is preceeded by low dosages of diethyldithocarbamate (DDC). However, if the dosage of DDC is high enough to potentiate the neurotoxicity associated with MPTP, thymic and spleen involution occur suggesting this dosing regimen may impair immune function. Thus, the immunotoxic and neurotoxic effects of the high dose regimen were studied.
Supplementary Notes Prepared in cooperation with Wellcome Research Labs., Research Triangle Park, NC.
Category Codes 57Y; 57J
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 128229344
Origin NTIS
Type CAT