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OLS Field Name OLS Field Data
Main Title Assessment of Chemically-Induced Alterations in Brain Development Using Assays of Neuron- and Glia-Localized Proteins.
Author O'Callaghan, J. P. ; Miller, D. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/438;
Stock Number PB91-109306
Additional Subjects Toxicology ; Brain ; Nerve cells ; Reprints ; Ontogeny ; Neuroglia ; Encephalitogenic basic proteins ; Glial fibrillary acidic protein ; Organotin compounds
Holdings
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NTIS  PB91-109306 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/04/1991
Collation 16p
Abstract Chemical intervention during prenatal or postnatal ontogeny can result in complex biochemical, morphological and behavioral alterations in brain development. As has been shown at the conference, the knowledge of specific actions of a given drug/chemical in the adult can serve as a guide for choosing processes affected by the same compound administered during development. Commonly, however, the neuronal or glial substrates for chemical action in the developing brain are not known and cannot be easily predicted on the basis of effects observed in the mature animal. Indeed, there are a multitude of structurally dissimilar compounds that affect diverse and unpredictable targets in the developing brain. The focus of the review is to present an approach for detecting and characterizing chemically-altered brain development that can be used regardless of the information available on the chemical in question. (Copyright (c) 1989 by Intox Press, Inc.)
Supplementary Notes Pub. in NeuroToxicology (Trade Name), v10 n3 p393-406 Sep 89. Presented at the International Neurotoxicology Conference (6th), Little Rock, AR., October 10-14, 1988.
NTIS Title Notes Journal article.
Title Annotations Reprint: Assessment of Chemically-Induced Alterations in Brain Development Using Assays of Neuron- and Glia-Localized Proteins.
Category Codes 57Y; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 034834476
Origin NTIS
Type CAT