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RECORD NUMBER: 4 OF 21

OLS Field Name OLS Field Data
Main Title Changes in Testicular and Serum Hormone Concentratios in the Male Rat Following Treatment with 'm'-Dinitrobenzene (Journal Version).
Author Rehnberg, G. L. ; Linder, R. E. ; Goldman, J. M. ; Hein, J. F. ; McElroy, W. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1988
Year Published 1988
Report Number EPA/600/J-88/203;
Stock Number PB89-144455
Additional Subjects Toxicity ; Hormones ; Testes ; Blood serum ; Gonadotropins ; Hypothalamus ; Nitroaryl compounds ; Pituitary gland ; Atrophy ; Rats ; Testosterone ; Reproductive system ; Reprints ; Dinitrobenzenes ; Biological effects ; Epithelium
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB89-144455 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/08/1989
Collation 12p
Abstract m-Dinitrobenzene (m-DNB)-induced testicular atrophy has been attributed to a direct effect upon the germinal epithelium. However, such degenerative changes in the germinal epithelium should induce shifts in the testicular hormonal milieu, which would in turn alter the hypothalmic-pituitary gonadal axis in general. The study evaluated the endocrine status of male rats following a single oral dose of m-DNB (32 mg m-DNB/kg). Serum and pituitary leuteinizing hormone, follicle-stimulating hormone (FSH), and protactin and hypothalamic gonadotropin-releasing hormone (GnRH) concentrations were determined. Testosterone and androgen-binding protein concentrations in serum, interstitial fluid, seminiferous tubule fluid, and caput epididymis were also determined. In vitro basal and hCG-stimulated testosterone release was determined in the decapsulated testis. These data demonstrate that m-DNB exerts a direct effect on the testes and not through alterations in hypothalamic and pituitary control of gonadal function. (Copyright (c) 1988 Academic Press, Inc.)
Supplementary Notes Pub. in Toxicology and Applied Pharmacology, v95 p255-264 1988.
NTIS Title Notes Journal article.
Title Annotations Reprint: Changes in Testicular and Serum Hormone Concentratios in the Male Rat Following Treatment with 'm'-Dinitrobenzene (Journal Version).
Category Codes 57Q; 57Y; 57E
NTIS Prices PC A03/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 908927629
Origin NTIS
Type CAT