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OLS Field Name OLS Field Data
Main Title Relationship between the Metabolism of Haloacetonitriles and Chloroform and Their Carcinogenic Activity.
Author Pereira, M. A. ; Daniel, F. B. ; Lin, E. L. C. ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1984
Report Number EPA/600/D-84/203;
Stock Number PB84-246230
Additional Subjects Carcinogens ; Potable water ; Water treatment(Chemicals) ; Halogen organic compounds ; Chloroform ; Metabolism ; Laboratory animals ; Toxicology ; Chlorination ; In vitro analysis ; Deoxyribonucleic acids ; Public health ; Acetonitriles ; Water pollution effects(Humans) ; Acetonitrile/chloro ; Acetonitrile/dichloro ; Acetonitrile/bromo-chloro ; Acetonitrile/trichloro
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB84-246230 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 19p
Abstract Halogenated acetonitriles, found in chlorinated drinking water, are formed by the reaction of chlorine with algae, fulvic acid, and proteinaceous material in the source water. The metabolism of halogenated acetonitriles was investigated in relation to their possible carcinogenic activity. Chloroacetonitrile (CAN), dibromoacetonitrile (DBAN), dichloroacetonitrile (DCAN), bromochloroacetonitrile (BCAN), and trichloroacetonitrile (TCAN) were shown to bind the nucleophilic trapping agent, p-nitrobenzylpyridine, without metabolic activation and to produce strand breaks in the DNA of cultured human CCRF-CEM cells. In addition, DCAN bound DNA in vitro without metabolic activation producing an adduct to adenine, and DBAN bound rat-liver DNA following oral administration.
PUB Date Free Form Sep 84
Category Codes 6T; 6E; 68D; 68G; 57Y; 57U
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 435627706
Origin NTIS
Type CAT