||DNA Adducts as Biomarkers for Assessing Exposure to Polycyclic Aromatic Hydrocarbons in Tissues from Xuan Wei Women with High Exposure to Coal Combustion Emissions and High Lung Cancer Mortality.
Mumford, J. L. ;
Lee, X. ;
Lewtas, J. ;
Young, T. L. ;
Santella, R. M. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Institute of Environmental Health and Engineering, Beijing (China). ;Columbia Univ., New York.
DNA adducts ;
Indoor air pollution ;
Biological markers ;
Air pollution effects(Humans) ;
Enzyme-linked immunosorbent assay ;
Natural gas ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The high lung cancer rate in Xuan Wei, China, is associated with smoky coal use in unvented homes. Smoky coal combustion emits higher levels of polycyclic aromatic hydrocarbons (PAH) than wood combustion. The study used DNA adducts as a biomarker for human exposure to PAH from combustion emissions. DNA adducts were determined by enzyme-linked immunosorbent assays (ELISA) in placentas and peripheral and cord white blood cells from Xuan Wei women burning smoky coal or wood and from Beijing women using natural gas. Color ELISA gave positive results in 58%, 47%, and 5% of the placentas from Xuan Wei women burning smoky coal without and with chimneys, and from Beijing women, respectively. Fluorescence ELISA indicated that 46%, 65%, 56%, and 25% of placentas were positive from Xuan Wei women without and with chimneys, Xuan Wei women burning wood, and Beijing controls, respectively. PAH-DNA adducts were detected in a higher percentage of placentas from Xuan Wei women exposed to smoky coal or wood emissions than those of the Beijing controls. The results suggest that DNA adducts can be used as a qualitative biomarker to assess human exposure to combustion emissions.
||Pub. in Environmental Health Perspectives, v99 p83-87 Mar 93. See also PB88-104179. Prepared in cooperation with Institute of Environmental Health and Engineering, Beijing (China), and Columbia Univ., New York.
|NTIS Title Notes
||Reprint: DNA Adducts as Biomarkers for Assessing Exposure to Polycyclic Aromatic Hydrocarbons in Tissues from Xuan Wei Women with High Exposure to Coal Combustion Emissions and High Lung Cancer Mortality.
||68G; 68A; 57Y; 57F; 97K
||PC A02/MF A01