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OLS Field Name OLS Field Data
Main Title Transposons and the Dynamic Genome [electronic resource] /
Author Lankenau, Dirk-Henner.
Other Authors
Author Title of a Work
Volff, Jean-Nicolas.
Publisher Springer Berlin Heidelberg,
Year Published 2009
Call Number QD415-436
ISBN 9783642020056
Subjects Life sciences. ; Human genetics. ; Biochemistry. ; Cytology.
Internet Access
Description Access URL
Collation XV, 184 p. online resource.
Notes Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes Theoretical Approaches to the Dynamics of Transposable Elements in Genomes, Populations, and Species -- Infra- and Transspecific Clues to Understanding the Dynamics of Transposable Elements -- Morphological Characters from the Genome: SINE Insertion Polymorphism and Phylogenies -- Genome Defense Against Transposable Elements and the Origins of Regulatory RNA -- When Drosophila Meets Retrovirology: The gypsy Case -- Transposon-Host Cell Interactions in the Regulation of Sleeping Beauty Transposition -- Interactions of Transposons with the Cellular DNA Repair Machinery. There are only few major key functions that lie beneath the fundamental architecture of metabolism and life. These are multiplication, variation and heredity. Only if these factors interact synergistically can Darwinian selection power the evolution of biodiversity. Transposable elements have always played a major role in this process. The genomes of all organisms consist of chromosomes that are built up of double-stranded nucleic acid chains on whose stability and integrity the existence of cells depend. While DNA repair warrants the chemical integrity of DNA and protects it from metabolic and environmental mutagens, meiotic recombination and transposable element activity appear to counteract the molecular guardians of genome stability. Transposable elements and their kind often make up the bulk of genomic DNA, often approaching 50% of the genome. By contrast, the classic genes represent as little as 1.8% of genomic DNA, in case of the human genome. This volume gives an overview on mobile DNA and how such contradiction to the obligatory stability of genomes can be understood. Obviously, an understanding can only be achieved by cutting deeply into the evolutionary history of life along with the evolution of transposable elements and dynamic genomes. This book therefore also celebrates Charles Darwin's 200th birthday. The reader is challenged to view the role of movable DNA along historical roots from the levels of cells to populations to biological species integrating the accompanying molecular evolution of host, cell and genome interaction. One will witness even the reactivation of a long since dead, fossil transposable element and the infection of germline cells by the first established, mobile and endogenous insect retrovirus.
Place Published Berlin, Heidelberg
Corporate Au Added Ent SpringerLink (Online service)
Title Ser Add Ent Genome Dynamics and Stability, 4
Host Item Entry Springer eBooks
PUB Date Free Form 2009
Series Title Untraced Genome Dynamics and Stability, 4
BIB Level m
Medium computer
Content text
Carrier online resource
Cataloging Source OCLC/T
OCLC Time Stamp 20140911025103
Language eng
OCLC Rec Leader 03940nam a22004935i 45