||Toxicology of Abate in Laboratory Animals.
Gaines, Thomas B. ;
Kimbrough, Ranate ;
Laws, Jr., Edward R. ;
||National Communicable Disease Center, Atlanta, Ga.
Cholinesterase inhibitors ;
Phosphorus organic compounds ;
Lethal dosage ;
Laboratory animals ;
Signs and symptoms ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||In laboratory animals Abate produces signs, symptoms, and type of death typical of those associated with other organic phosphorus compounds. In large enough doses Abate will inhibit cholinesterase, and it does this more promptly and to a greater extent for RBC cholinesterase than for plasma cholinesterase. The acute oral lethal dose (LD50) for Abate in rats and male mice is 4,000 mg/kg or greater. Restrained female rats tolerate a dermal dose of Abate of 4,000 mg/kg without clinical effect, but the same dosage killed two of ten males. Rats, rabbits, guinea pigs, and chickens tolerate a daily oral dosage of Abate of 10 mg/kg without observable clinical effect, and dogs tolerate a daily dosage of 3 to 4 mg/kg, the highest rate at which they were dosed. Rats and rabbits tolerate at a dosage of 1 mg/kg/day for extended periods of time without detectable effect on cholinesterase.
||Pub. in Archives of Environmental Health, v14 p283-288, Feb 67.
||Included in the report, Journal Articles on Toxicology. Group 4, PB-279 272.
||Reprint: Toxicology of Abate in Laboratory Animals,
|PUB Date Free Form
||23 Aug 66
||6T; 57Y; 68E; 68G
||(Order as PB-279 272, MF A01)