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OLS Field Name OLS Field Data
Main Title Toxicity of Metepa to Rats, With Notes on Two Other Chemosterilants.
Author Gaines, Thomas B. ; Kimbrough., Renate D. ;
CORP Author Communicable Disease Center, Atlanta, Ga.
Year Published 1964
Stock Number PB-280 837
Additional Subjects Toxicology ; Laboratory animals ; Bioassay ; Ingestion(Biology) ; Rats ; Skin(Anatomy) ; Experimental data ; Dosage ; Reproductive system ; Testis ; Ovary ; Bone marrow ; Sterility ; Histology ; Males ; Fertility ; Phosphorus organic compounds ; Reprints ; Chemosterilants ; Toxic substances ; Tepa ; Metepa ; Apholate ; Phosphine oxide/tris(aziridinyl) ; Phosphine oxide/tris(methyl-aziridinyl)
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NTIS  PB-280 837 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 9p
Abstract Although tepa, metepa, and apholate are only moderately toxic to rats by the oral route, the dermal toxicity of the first two is relatively high as compared with that of conventional insecticides. In the experiments reported, metepa caused no damage to he intestinal epithelium of rats, except following single doses in the fatal range. The organ primarily affected by repeated small doses of metepa is the testis; the ovaries and bone marrow are damaged only by higher dosage levels. Metepa at an oral dosage of 5 mg/kg/day (about 4% of the acute oral LD50 level daily) produced severe reduction of fertility of male rats within 22 days, sterility within 70 days, and testicular atrophy within 77 days. Half that dosage produced a smaller reduction in fertility and only partial testicular atrophy in some rats within 197 days. Dosages of 1.25 mg/kg/day or less produced no detectable effect on fertility and no histological change in the testis in 197 days. The survival of newborn rats was not affected by any dosage given to their sires.
Supplementary Notes Pub. in Bull. Wld Hlth Org., 31 p737-745 1964. Summary in French.
Availability Notes Included in the report, Journal Articles on Toxicology. Group 16, PB-280 830.
Title Annotations Reprint: Toxicity of Metepa to Rats, With Notes on Two Other Chemosterilants,
PUB Date Free Form 1964
Category Codes 6T; 57Y
NTIS Prices (Order as PB-280 830, MF A01)
Primary Description 500/01
Document Type NT
Cataloging Source NTIS/MT
Control Number 323740948
Origin NTIS
Type CAT