||Functional Teratogens of the Rat Kidney. 2. Nitrofen and Ethylenethiourea.
Daston, G. P. ;
Rehnberg, B. F. ;
Carver, B. ;
Kavlock., R. J. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Wisconsin Univ.-Milwaukee. Dept. of Biological Sciences.
Aromatic polycyclic hydrocarbons ;
Proximal kidney tubules ;
Kidney concentrating ability
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||Nitrofen and enthylenethiourea (ETU), agents known to prenatally induce hydronephrosis in rats, were assessed for their effects on postnatal renal functional maturation. Both were given by gavage to pregnant Sprague-Dawley rats on Gestation Day 11. Nitrofen was given at concentrations of 50 or 100 mg/kg, and ETU at 20, 40, or 60 mg/kg. Renal function was examined in the offspring from birth until after weaning, the period of renal functional maturatiOn in the rat. Maximal urine concentrating ability was measured after DDAVP (desmopressin acetate, a vasopressin analog) challenge or water deprivation. Proximal tubule transport was measured in rEnal cortical slices. Various urinary parameters were measured. Both prenatal nitrofen and ETU exposure caused a large number of neonatal deaths at the high dose, and hydronephrosis was observed. The severity of the lesion increased with age. Hydronephrotic animals were deficient in urine concentrating ability, which became more pronounced after weaning. A few other urinary parameters were altered, but cortical function appeared to be unaffected. (Copyright (c) 1988 by the Society of Toxicology.)
||Pub. in Fundamental and Applied Toxicology, v11 n3 p401-415 Oct 88. Prepared in cooperation with Wisconsin Univ.-Milwaukee. Dept. of Biological Sciences.
|NTIS Title Notes
||Reprint: Functional Teratogens of the Rat Kidney. 2. Nitrofen and Ethylenethiourea.
||PC A03/MF A01