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RECORD NUMBER: 29 OF 74

OLS Field Name OLS Field Data
Main Title Effects on the Fetus of Maternal Nitrofen Exposure in the Protein-Deprived Rat.
Author Zeman, F. J. ; Hoogenboom, E. R. ; Chase-Deesing, C. ; Kavlock, R. J. ; Semple, J. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;California Univ., Davis.
Year Published 1986
Report Number EPA/600/J-86/073;
Stock Number PB86-212669
Additional Subjects Toxicology ; Exposure ; Rats ; Pregnancy ; Diet ; Laboratory animals ; Reprints ; Protein deprivation ; Nitrofen
Holdings
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Status
NTIS  PB86-212669 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 15p
Abstract The separate and combined effects of protein deprivation and nitrofen exposure were studied in the pregnant rat. Animals were fed diets containing 24, 8, 6 or 4% casein throughout gestation. Within each diet group, sub-groups were gavage-fed with 12.5 (lower dose) and 25 (higher dose) mg nitrofen/kg body weight or with oil carrier only on days 7-21 of gestation. Dams were weighed and food intake was measured daily. On day 21 of gestation, cesarean-derived pups were examined for congenital anomalies and dissected for determination of organ weights. Skeletons were alizarin stained and examined for skeletal anomalies and developmental stage. No effects on the skeleton or gross congenital anomalies were seen. Fetal, size and weights of liver, kidney, intestine, heart, lung and brain were reduced with decreasing casein content of the diet and as a result of the higher dose of nitrofen.
Supplementary Notes Pub. in Toxicology 38, p55-68 1986. Prepared in cooperation with California Univ., Davis.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effects on the Fetus of Maternal Nitrofen Exposure in the Protein-Deprived Rat.
PUB Date Free Form c1986
Category Codes 6T; 57Y
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 624111584
Origin NTIS
Type CAT