||Effects on the Fetal Rat Intestine of Maternal Malnutrition and Exposure to Nitrofen (2,4-Dichlorophenyl-p-Nitrophenyl Ether).
Mahboob, S. ;
Hoogenboom, E. R. ;
Kavlock, R. J. ;
Zeman, F. J. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;California Univ., Davis.
Laboratory animals ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The effects of maternal protein-energy malnutrition and exposure to nitrofen on selected aspects of intestinal morphology and function were studied in the fetal rat. Pregnant rats were fed, throughout gestation, diets containing 24% or 6% casein as the sole source of protein. Reduced total food intake produced protein-energy malnutrition (PEM). Each diet group was divided in half and gavaged with either 12.5 mg nitrofen in corn oil/kg/day or corn oil carrier only from days 7 to 21 of gestation. Body weight, intestinal weight, length, and diameter were measured as were villus length (VL), villus width (VW), and number of villi per length of intestine (VMM). Protein (horseradish peroxidase) and lipid absorption were studied histochemically. Lactase and dipeptidase activities were determined in proximal, medial, and distal thirds of the intestine. Results showed that the restricted maternal diet resulted in reduced fetal body weight (BW), intestinal weight (IW) and length (IL), reduced IW/BW and IW/IL ratios, VH, and VMM. The VW was reduced only in the distal third.
||Pub. in Teratogenesis, Carcinogenesis, and Mutagenesis, v6 n6 p45-57 Jan 86. Prepared in cooperation with California Univ., Davis.
|NTIS Title Notes
||Reprint: Effects on the Fetal Rat Intestine of Maternal Malnutrition and Exposure to Nitrofen (2,4-Dichlorophenyl-p-Nitrophenyl Ether).
|PUB Date Free Form
||PC A02/MF A01