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RECORD NUMBER: 32 OF 74Main Title | Extraction of Phenol and Its Metabolites from Aqueous Solution. | |||||||||||
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Author | Jones, L. A. ; Prabel, J. B. ; Glennon, J. J. ; Copeland, M. F. ; Kavlock, R. J. ; | |||||||||||
CORP Author | North Carolina State Univ. at Raleigh. Dept. of Chemistry.;Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. | |||||||||||
Publisher | c1993 | |||||||||||
Year Published | 1993 | |||||||||||
Report Number | EPA/600/J-93/334; | |||||||||||
Stock Number | PB93-229524 | |||||||||||
Additional Subjects | Phenols ; Extraction ; Aqueous solutions ; Biological effects ; Analytic techniques ; Pharmacokinetics ; Salting-out agents ; Laboratory animals ; Chemical analysis ; Toxicology ; Environmental effects ; Tetrahydrofuran ; Acetonitrile ; Metabolism ; Biochemistry ; Reprints ; Formamide/dimethyl ; Acetic acid/(ethyl-ester) ; Ether/diethyl | |||||||||||
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Collation | 9p | |||||||||||
Abstract | As part of an ongoing pharmacokinetic investigation of the teratogenicity of phenol and its metabolites (1,2-, 1,3-, and 1,4-dihydroxybenzene) in pregnant Sprague-Dawley rats, there was need of an analytical procedure sufficiently sensitive to provide quantitative data to the parts-per-billion level or better in urine, plasma, and fetal tissue. In the development of an extraction method utilizing the 'salting out' technique, the extraction efficiencies of phenol, catechol, resorcinol, and hydroquinone from aqueous solutions were determined for tetrahydrofuran (THF), acetonitrile (ACN), dimethylformamide (DMF), ethyl acetate (EtOAc), and diethyl ether (Et2O). The inorganic salts of potassium fluoride (anhydrous), sodium chloride, lithium chloride, ammonium acetate, and sodium bicarbonate were used to saturate the solvent/water combinations. Phase separations were not observed for THF/LiCl, NaHCO3; ACN/NaHCO3; and DMF/NaCl, LiCl, NH4OAc, NaHCO3, whereas ACN/KF produced quinone while DMF/KF yielded no hydroquinone in non-acidified solutions. Essentially all other solvent/salt combinations gave quantitative recoveries, while KF was found to be an efficient drying agent. | |||||||||||
Supplementary Notes | Pub. in Jnl. of Agriculture and Food Chemistry, v41 n5 p735-741 May 93. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. | |||||||||||
NTIS Title Notes | Journal article. | |||||||||||
Title Annotations | Reprint: Extraction of Phenol and Its Metabolites from Aqueous Solution. | |||||||||||
Category Codes | 99A; 57B; 57Y; 68 | |||||||||||
NTIS Prices | PC A02/MF A01 | |||||||||||
Primary Description | 600/10 | |||||||||||
Document Type | NT | |||||||||||
Cataloging Source | NTIS/MT | |||||||||||
Control Number | 328023516 | |||||||||||
Origin | NTIS | |||||||||||
Type | CAT |