Full Record Display for the EPA National Library Catalog

RECORD NUMBER: 9 OF 17

OLS Field Name OLS Field Data
Main Title Functional Deficits Produced by 3-Methylindole-Induced Olfactory Mucosal Damage Revealed by a Simple Olfactory Learning Task.
Author Peele, D. B. ; Allison, S. D. ; Bolon, B. ; Prah, J. D. ; Jensen, K. F. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. ;Chemical Industry Inst. of Toxicology, Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/018;
Stock Number PB91-183483
Additional Subjects Toxicology ; Skatole ; Nasal mucosa ; Rats ; Sensory thresholds ; Cognition ; Animal behavior ; Pathology ; Reprints ; Olfactory learning
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB91-183483 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/04/1991
Collation 14p
Abstract Methods for assessing functional consequences of olfactory mucosal damage were examined in rats exposed to 3-methylindole (3-MI). Treatment with 3-MI (400 mg/kg) induced severe degeneration of olfactory sensory epithelium followed by regeneration, fibrous adhesions and osseous remodeling of the nasal passages. At 100 mg/kg, there was mild Bowman's gland hypertrophy while the sensory epithelium remained intact. Rats treated with 3-MI demonstrated a dosage-related deficit in acquiring an olfactory learning task which was not due to altered cognitive abilities, as determined by subsequent testing in a step-through passive avoidance task. The results confirm the conclusion that alterations in functional indices resulted from 3-MI-induced anosmia and demonstrate the utility of simple learning tasks in assessing functional capacity following olfactory epithelial damage in rats. (Copyright (c) 1991 Academic Press, Inc.)
Supplementary Notes Pub. in Toxicology and Applied Pharmacology, v107 n2 p191-201 Feb 91. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC., and Chemical Industry Inst. of Toxicology, Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Functional Deficits Produced by 3-Methylindole-Induced Olfactory Mucosal Damage Revealed by a Simple Olfactory Learning Task.
Category Codes 57U; 57S
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 117927397
Origin NTIS
Type CAT