||Comparison of the D1-Dopamine Agonists SKF-38393 and A-68930 in Neonatal 6-Hydroxydopamine-Lesioned Rats: Behavioral Effects and Industion of c-fos-Like Immunoreactivity.
Johnson, K. B. ;
Criwell, H. E. ;
Jensen, K. F. ;
Simson, P. E. ;
Mueller, R. A. ;
||North Carolina Univ. at Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Dopamine receptors ;
Proto-oncogene proteins c-fos ;
Corpus striatum ;
Animal behavior ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Administration of the selective D1-dopamine receptor agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (SKF-38393) to neonatal 6-hydroxydopamine-lesioned rats results in profound behavioral manifestations and induction of striatal c-fos-like immunoreactivity. The full D1-dopamine agonist l,(R,S)1-aminomethyl-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran hydrochloride (A-68930), like SKF-38393, produced a dose-dependent, D1-selective increase in locomotor activity and striatal c-fos-like immunoreactivity. These results with A-68930 provide additional evidence that the specific behavioral and biochemical responses observed in neonatally lesioned rats after SKF-38393 administration are due to actions on D1-dopamine receptors, and indicate that A-68930 provides a new tool for investigating D1-dopamine receptor function.
||Pub. in Jnl. of Pharmacology and Experimental Therapeutics, v262 n2 p855-865 Aug 92. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
|NTIS Title Notes
||Reprint: Comparison of the D1-Dopamine Agonists SKF-38393 and A-68930 in Neonatal 6-Hydroxydopamine-Lesioned Rats: Behavioral Effects and Industion of c-fos-Like Immunoreactivity.
||PC A03/MF A01