Main Title |
Toxicological Evaluation of Selected Chlorinated Phenols. |
Author |
Borzelleca, J. F. ;
Condie, L. W. ;
Hayes, J. R. ;
|
CORP Author |
Medical Coll. of Virginia, Richmond. Dept. of Pharmacology.;Health Effects Research Lab., Cincinnati, OH. |
Year Published |
1984 |
Report Number |
EPA-R-808861; EPA/600/D-84/234; |
Stock Number |
PB85-101772 |
Additional Subjects |
Toxicology ;
Phenols ;
Chlorine organic compounds ;
Water pollution ;
Laboratory animals ;
Dosage ;
Exposure ;
Potable water ;
Liver ;
Phenol/pentachloro ;
Phenol/chloro ;
Phenol/dichloro
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB85-101772 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
24p |
Abstract |
Toxicology studies were conducted with the mono-, di-, and pentachlorophenols (CP). Chlorophenols (except PC) demonstrate a relatively low order of toxicity. The order of toxicity in mice and rats (most to least) is: PCP > tetra CPs > mono CPs > tri CPs > di CPs. Short-term (14 days) repeated exposure to 2-CP at (gavage) doses of 35, 69, or 175 mg/kg/day (approximately 1/10, 1/5, 1/2 the acute oral LD50) resulted in 100% lethality at the highest dose and no biologically significant compound related effects at the lower doses. Short-term (14 days) repeated exposure to 2,4-DCP at (gavage) doses of 64, 128, or 638 mg/kg/day (approximately 1/20, 1/10, 1/2 the acute oral LD50) failed to induce significant compound related toxicity. The liver was identified as a possible target organ. Subchronic exposure to 2,4-DCP at drinking water concentrations of 0.2, 0.6, and 2.0 mg/ml (limit of solubility and acceptability was 2.0 mg/ml) for 90 days (approximate doses of 50, 150, 500 mg/kg/day) failed to induce significant compound related toxicity. The data presented and a review of the available literature support the relatively low order of toxicity of most chlorinated phenols ingested orally (except PCP). |
PUB Date Free Form |
Sep 84 |
Category Codes |
6T; 68D; 57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
500424203 |
Origin |
NTIS |
Type |
CAT |