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OLS Field Name OLS Field Data
Main Title Myelin Basic Protein-Messenger RNA (MBP-mRNA) Expression during Triethyltin-Induced Myelin Edema.
Author Veronesi, B. ; Jones, K. ; Gupta, S. ; Pringle, J. ; Mezei, C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;Dalhousie Univ., Halifax (Nova Scotia). Dept. of Biochemistry.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-92/072;
Stock Number PB92-150861
Additional Subjects Encephalitogenic basic proteins ; Messenger RNA ; Gene expression ; Edema ; Trimethyltin compounds ; Toxicity ; Rats ; Brain ; Nucleic acid hybridization ; Northern blotting ; Electron microscopy ; DNA probes ; Optic nerve ; Reprints ;
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NTIS  PB92-150861 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/28/1992
Collation 14p
Abstract Triethyltin (TET) is a neurotoxicant that produces severe but transient cerebral edema, characterized ultrastructurally by vacuolation of the intraperiod line of central nervous system (CNS) myelin. In the present study, the genomic expression (i.e., mRNA) of MBP was monitored throughout the pathogenesis of TET-induced myelin edema and recovery in Sprague-Dawley rats given a single injection of a neuropathic (8.0 mg/kg) or non-neuropathic (0.8 mg/kg) dose of TET-bromide. Levels of MBP-mRNA from the anterior and posterior brain were collected 1 hr, 3 hr, 2d, and 7d, postexposure. The optic nerve andd caudal brainstem, representing anterior and posterior brain sites, respectively, were examined at the same time-points for ultrastructural evidence of edema and recovery. Study data indicate that neuropathic doses (8.0 mg/kg) of TET significantly stimulated MBP transcript throughout the brain at all exposure time-points. The magnitude and time-course of this stimulation differed in the anterior and posterior brain, with the latter region showing higher levels of MBP-mRNA.
Supplementary Notes Pub. in Neurotoxicology, v12 n2 p265-276 Jul 91. See also PB91-231274. Prepared in cooperation with Dalhousie Univ., Halifax (Nova Scotia). Dept. of Biochemistry.
NTIS Title Notes Journal article.
Title Annotations Reprint: Myelin Basic Protein-Messenger RNA (MBP-mRNA) Expression during Triethyltin-Induced Myelin Edema.
Category Codes 57F; 57Y
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 211522994
Origin NTIS
Type CAT