Main Title |
Teratogenic Effects of the Fungicide Dinocap in the Mouse. |
Author |
Rogers, J. M. ;
Carver, B. ;
Gray, L. E. ;
Gray, J. A. ;
Kaylock, R. J. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1986 |
Report Number |
EPA/600/J-86/371; |
Stock Number |
PB87-198511 |
Additional Subjects |
Fungicides ;
Teratoma ;
Congenital abnormalities ;
Mice ;
Cleft palate ;
Embryos ;
Pregnancy ;
Reprints ;
Dinitrobenzenes ;
Teratogens ;
Abnormalities drug induced ;
Fetal growth retardation ;
Dose response relationship drug
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB87-198511 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
The teratogenic potential of the fungicide dinocap was evaluated in CD-1 mice. Pregnant mice were dosed by intubation with dinocap in corn oil on gestation days 7-16. Doses used were 0, 5, 10, 20, 40, 80, and 120 mg/kg/day, based on d 6 weight. Dams were killed on d 18, at which time fetuses were counted, weighed, and preserved for necropsy or skeletal examination. The highest dose killed 80% of the dams dosed, while 29% of the dams in the 80 mg/kg group died during dosing. There was no dose-related maternal mortality at lower doses. Net maternal weight gain was affected only at 80 mg/kg/day. There were no live fetuses at 120 mg/kg/day. The number of live fetuses per litter was decreased and resorptions increased at 80 mg/kg. This study shows that dinocap is teratogenic in the CD-1 mouse at doses well below those causing maternal toxicity. |
Supplementary Notes |
Pub. in Teratogenesis, Carcinogenesis, and Mutagenesis 6, p375-381 1986. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Teratogenic Effects of the Fungicide Dinocap in the Mouse. |
PUB Date Free Form |
1986 |
Category Codes |
57Y; 57O |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
723226648 |
Origin |
NTIS |
Type |
CAT |