| Main Title |
Morphometric, Biochemical, and Physiological Assessment of Perinatally Induced Renal Dysfunction. |
| Author |
Kavlock, Robert J. ;
Gray, Jacqueline ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1983 |
| Report Number |
EPA-600/J-83-006; |
| Stock Number |
PB83-189084 |
| Additional Subjects |
Toxicology ;
Bioassay ;
Rats ;
Laboratory animals ;
Embryos ;
Reprints ;
Renal dysfunction ;
Chlorambucil ;
Nitrofen ;
Mercuric chloride
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-189084 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
15p |
| Abstract |
Three chemicals, known either to alter renal development when administered during fetal development or to affect renal function when administered to adult rats, were administered to Sprague-Dawley rats at critical periods of renal development. Chlorambucil (CHL) was administered ip on d 11 of gestation at doses of 0.3 and 6 mg/kg; nitrofen (2,4-dichlorophenyl p-nitrophenyl ether) (NIT) was given po on d 8-16 of gestation at 0.4.17, 12.5, and 25 mg/kg.d and mercuric chloride (MER) was given sc on postnatal d 1 at 0.14, and 28 micrograms/pup. To assess the effects of these toxicants on the functional development of the kidneys, a diuresis test with and without antidiuretic hormone was applied on postnatal d 3 (PD 3); a hydropenia test on PD 6; and kidney weights, glomerular counts in midhilar cross sections, and the specific activity of renal alkaline phosphatase were determined on PD 3 and 6. |
| Supplementary Notes |
Pub. in Jnl. of Toxicology and Environmental Health 11, p1-13 1983. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Morphometric, Biochemical, and Physiological Assessment of Perinatally Induced Renal Dysfunction. |
| PUB Date Free Form |
1983 |
| Category Codes |
6T; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
320322913 |
| Origin |
NTIS |
| Type |
CAT |
