||Comparison of the Pathogenesis of Murine Cytomegalovirus in Lung and Liver Following Intraperitoneal or Intratracheal Infection.
Selgrade, M. K. ;
Collier, A. M. ;
Saxton, L. ;
Daniels, M. J. ;
Graham, J. A. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill.
Laboratory animals ;
Murine cytomegalovirus ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||This study compares the pathogenesis of murine cytomegalovirus (MCMV) infections following intraperitoneal (I.P.) and intratracheal (I.T.) inoculation. No deaths were seen in mice given 1,000,000 pfu MCMV I.T., whereas 52% mortality occurred among animals given this dose I.P. This difference in mortality was not due to different effects on the lung since virus titers in this organ on progressive days post-infection were similar for the 2 routes of inoculation and similar, minor histopathologic changes were observed. In contrast, virus titers in the livers of mice inoculated I.P. were 100 fold higher than for those inoculated I.T., and histopathologic changes were noticeably greater in the I.P. group. Effects on liver function are the most likely explanation for the mortality seen following I.P. inoculation. Parallels between various forms of human cytomegalovirus infections and the types of infections seen following I.T. and I.P. MCMV infection were observed.
||Prepared in cooperation with North Carolina Univ. at Chapel Hill.
||Pub. in Journal of General Virology 65, p515-523 1984.
|NTIS Title Notes
||Reprint: Comparison of the Pathogenesis of Murine Cytomegalovirus in Lung and Liver Following Intraperitoneal or Intratracheal Infection.
|PUB Date Free Form
||6E; 6M; 57E; 57K
||Not available NTIS