||Influence of Ozone on Pentobarbital Pharmacokinetics in Mice.
Graham, J. A. ;
Menzel, D. B. ;
Mole, M. L. ;
Miller, F. J. ;
Gardner, D. E. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Duke Univ., Durham, NC.
Laboratory animals ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||It had been shown that 3 to 5 hr exposures to ambient concentrations of ozone (O3) increase pentobarbital-induced sleeping time in female mice, hamsters, and rats without decreasing heptatic cytochrome P-450 levels or selected mixed function oxidases. To elucidate potential mechanisms involved, clearance of pentobarbital from the blood of O3-exposed mice was examined. Pentobarbital clearance followed first-order kinetics with a one-compartment model. Mice exposed to 1960 micrograms per cu. m. (1ppm) for 5 hr had a 71% increase in the plasma half-life of pentobarbital. It therefore appears possible that pentobarbital-induced sleeping time is increased due to a decrease in hepatic metabolism of pentobarbital.
||Pub. in Toxicology Letters 24, n2-3 p163-170 1985. Prepared in cooperation with Duke Univ., Durham, NC.
|NTIS Title Notes
||Reprint: Influence of Ozone on Pentobarbital Pharmacokinetics in Mice.
|PUB Date Free Form
||PC A02/MF A01