Main Title |
Thermoregulation in Mice Following Acute Chlordimeform Administration. |
Author |
Gordon, C. J. ;
Long, M. D. ;
Stead, A. G. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1985 |
Report Number |
EPA/600/J-85/347; |
Stock Number |
PB86-175429 |
Additional Subjects |
Toxicology ;
Thermoregulation ;
Mice ;
Laboratory animals ;
Reprints ;
Chlordimeform
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB86-175429 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
CBA/J mice were injected intraperitoneally with the formamidine insecticide chlordimeform (CDM) while colonic temperature, preferred ambient temperature (Ta), and lethality were monitored. In the first experiment there was a dose-dependent decrease in colonic temperature when measured 60 min after administering CDM doses of 0, 15, 30, 60, and 75 mg/kg. The hypothermic effect of CDM was more pronounced at a Ta of 20 C than at 30 C. In the second experiment CDM at doses greater than 30 mg/kg caused a dose dependent reduction in preferred Ta from the normal of approx. 30 C down to approx. 22 C. Thus, the CDM-treated mouse lowers body temperature by selecting a cool Ta which accelerates the hypothermic effect. In the final experiment, a 90 mg/kg i.p. injection of CDM (the approximate LD50 dose) caused 10% and 0% mortality at a Ta of 20 and 30 C, respectively, and 80% mortality at a Ta of 35 C. |
Supplementary Notes |
Pub. in Toxicology Letters 28, n1 p9-15 Oct 85. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Thermoregulation in Mice Following Acute Chlordimeform Administration. |
PUB Date Free Form |
1985 |
Category Codes |
6T; 57Y |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
614222698 |
Origin |
NTIS |
Type |
CAT |