Main Title |
Attenuation of Alcohol Consumption by MDMA (Ecstasy) in Two Strains of Alcohol-Preferring Rats. |
Author |
Rezvani, A. H. ;
Garges, P. L. ;
Miller, D. B. ;
Gordon, C. J. ;
|
CORP Author |
Environmental Protection Agency, Research Triangle Park, NC. Neurotoxicology Div. ;North Carolina Univ. at Chapel Hill. |
Publisher |
c1992 |
Year Published |
1992 |
Report Number |
EPA/600/J-92/424; |
Stock Number |
PB93-141232 |
Additional Subjects |
Alcohol drinking ;
Amphetamines ;
Serotonin ;
Rats ;
Water consumption ;
Body temperature ;
Drinking behavior ;
Alcoholism ;
Reprints ;
Methylenedioxymethamphetamine
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-141232 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Alcohol preference and manifestation of alcoholism are thought by many to be associated with serotonin (5-HT) dysfunction in the brain. Thus, experiments were performed to determine the effect of acute and sub-chronic administration (s.c.) of + or - 3,4-methylenedioxymethamphetamine (MDMA), an amphetamine analog which stimulates 5-HT release, on alcohol preference in two strains of alcohol preferring rats, the Fawn-Hooded (FH) and alcohol preferring (P) rats. Our results show that a single administration of 5.0 mg/kg MDMA significantly decreased ethanol intake in both FH and P rats and increased water intake. Sub-chronic administration of 5.0 mg/kg MDMA for three consecutive days significantly attenuated alcohol intake in both strains. |
Supplementary Notes |
Pub. in Pharmacology Biochemistry and Behavior, v43 n1 p103-110 Sep 92. Prepared in cooperation with North Carolina Univ. at Chapel Hill. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Attenuation of Alcohol Consumption by MDMA (Ecstasy) in Two Strains of Alcohol-Preferring Rats. |
Category Codes |
57S; 57T |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
200/04 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
307031306 |
Origin |
NTIS |
Type |
CAT |