Main Title |
Hypothermia and Hypometabolism: Sensitive Indices of Whole-Body Toxicity Following Exposure to Metallic Salts in the Mouse. |
Author |
Gordon, C. J. ;
Fogelson, L. ;
Highfill, J. W. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1990 |
Year Published |
1990 |
Report Number |
EPA/600/J-90/036; |
Stock Number |
PB90-217589 |
Additional Subjects |
Toxicity ;
Hypothermia ;
Metabolism ;
Chlorides ;
Metals ;
Exposure ;
Mice ;
Body temperature ;
Tables(Data) ;
Graphs(Charts) ;
Reprints ;
Lethal dose 50 ;
Oxygen consumption
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-217589 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
18p |
Abstract |
To investigate the practicality of hypothermia and hypometabolism as sensitive indices of toxicity in the mouse, oxygen consumption was monitored continuously and body temperature was measured at 30 min post-injection following the intraperitoneal administration of various metal salts. Eleven metal ions were tested: Al(3+), Cd(2+), Co(2+), Cr(2+), Cu(2+), Hg(2+), Mg(2+), Mn(2+), Ni(2+), Pb(2+), and Zn(2+). All metals induced dose-dependent reductions in both oxygen consumption (hypometabolism) and deep body (colonic) temperature. Comparative toxicity of the metal ions was evaluated by calculating the dose of metal ion in dimensions of mmole/kg body mass needed to reduce colonic temperature to 35C. The order of toxicity from lowest to highest was as follows: Cr
|
Supplementary Notes |
Pub. in Jnl. Toxicology and Environmental Health, v29 p185-200 Jan 90. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Hypothermia and Hypometabolism: Sensitive Indices of Whole-Body Toxicity Following Exposure to Metallic Salts in the Mouse. |
Category Codes |
57W; 57B; 57Y |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
019411263 |
Origin |
NTIS |
Type |
CAT |