Full Record Display for the EPA National Library Catalog

RECORD NUMBER: 17 OF 211

OLS Field Name OLS Field Data
Main Title Autonomic and Behavioral Thermoregulation in the Golden Hamster during Subchronic Administration of Clorgyline.
Author Gordon, C. J. ; Duncan, W. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;National Inst. of Mental Health, Rockville, MD. Clinical Psychobiology Branch.
Publisher cMay 94
Year Published 1994
Report Number EPA/600/J-94/530;
Stock Number PB95-148920
Additional Subjects Body temperature regulation ; Clorgyline ; Animal behavior ; Autonomic nervous system ; Pharmacology ; Monoamine oxidase inhibitors ; Mesocricetus ; Drug administration schedule ; Motor activity ; Feeding behavior ; Body weight ; Regression analysis ; Metabolism ; Reprints ; Golden hamsters
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB95-148920 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/06/1995
Collation 9p
Abstract Chronic administration of clorgyline, a type-A monoamine oxidase inhibitor, leads to a decrease in peritoneal (i.e., core) temperature of golden hamsters. To better understand the mechanisms of clorgyline's thermoregulatory effects, autonomic and behavioral thermoregulatory effectors were measured in Syrian hamsters following chronic infusion of clorgyline via a minipump (2 mg/kg/day). Metabolic rate, evaporative water loss, motor activity, and core temperature were measured after 60 min of exposure to ambient temperatures (T(sub a)) of 5, 20, 30, and 35 C. Behavioral thermoregulatory responses were assessed by measuring selected T(sub a) and motor activity of the same animals in a temperature gradient over the course of 23 h. Metabolic rate and motor activity were significantly elevated in clorgyline-treated hamsters exposed to a T(sub a) of 5 C. There were no effects of clorgyline on evaporative water loss. In the temperature gradient the mean selected T(sub a) of clorgyline-treated hamsters was nearly equal to that of the saline-treated hamsters, 30.7 and 31.2 C, respectively. On the other hand, the mode of selected T(sub a) in the clorgyline group was 2.8 C higher than that of the saline group. Motor activity in the gradient was significantly elevated and food consumption was depressed by clorgyline treatment.
Supplementary Notes Pub. in Pharmacology Biochemistry and Behavior, v48 n1 p119-125 May 94. See also PB92-124619. Prepared in cooperation with National Inst. of Mental Health, Rockville, MD. Clinical Psychobiology Branch.
NTIS Title Notes Journal article.
Title Annotations Reprint: Autonomic and Behavioral Thermoregulation in the Golden Hamster during Subchronic Administration of Clorgyline.
Category Codes 57Q; 57S
NTIS Prices PC A02/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 503415413
Origin NTIS
Type CAT