||Attenuation of Alcohol Consumption by MDMA (Ecstasy) in Two Strains of Alcohol-Preferring Rats.
Rezvani, A. H. ;
Garges, P. L. ;
Miller, D. B. ;
Gordon, C. J. ;
||Environmental Protection Agency, Research Triangle Park, NC. Neurotoxicology Div. ;North Carolina Univ. at Chapel Hill.
Alcohol drinking ;
Water consumption ;
Body temperature ;
Drinking behavior ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Alcohol preference and manifestation of alcoholism are thought by many to be associated with serotonin (5-HT) dysfunction in the brain. Thus, experiments were performed to determine the effect of acute and sub-chronic administration (s.c.) of + or - 3,4-methylenedioxymethamphetamine (MDMA), an amphetamine analog which stimulates 5-HT release, on alcohol preference in two strains of alcohol preferring rats, the Fawn-Hooded (FH) and alcohol preferring (P) rats. Our results show that a single administration of 5.0 mg/kg MDMA significantly decreased ethanol intake in both FH and P rats and increased water intake. Sub-chronic administration of 5.0 mg/kg MDMA for three consecutive days significantly attenuated alcohol intake in both strains.
||Pub. in Pharmacology Biochemistry and Behavior, v43 n1 p103-110 Sep 92. Prepared in cooperation with North Carolina Univ. at Chapel Hill.
|NTIS Title Notes
||Reprint: Attenuation of Alcohol Consumption by MDMA (Ecstasy) in Two Strains of Alcohol-Preferring Rats.
||PC A02/MF A01