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OLS Field Name OLS Field Data
Main Title Color Yes; Cancer No.
Author Freeman, H. ; Esancy, M. ; Esancy, J. ; Claxton, L. ;
CORP Author CIBA-GEIGY Corp., Raleigh, NC. ;Central Piedmont Community Coll., Charlotte, NC. ;Sandoz Chemicals Corp., Charlotte, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/244;
Stock Number PB92-110477
Additional Subjects Azo dyes ; Aniline compounds ; Toxicity ; Carcinogens ; Structure-activity relationships ; Chemical reactions ; Mutagens ; Dose-response relationships ; Reduction(Chemistry) ; Analogs ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB92-110477 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 02/24/1992
Collation 11p
Abstract Dyes based on known carcinogens such as benzidine and beta-naphthylamine can no longer be manufactured in the United States. In addition, numerous colorants have been banned from use by the food and cosmetic industries. These limitations have led to the examination of structure-activity relationships that could help in the development of suitable nongenotoxic dyes and dye precursors. The authors' goal was to demonstrate how nonmutagenic dyes could be developed by identifying nongenotoxic dyestuff intermediates. The authors' working hypothesis stated that an azo dye would be nonmutagenic if both the synthetic precursors and reductive cleavage products of the dye were nonmutagenic themselves. By examining a related series of compounds, the work was able to demonstrate the effect of adding specific substructural components to parent compounds used in the synthesis of dyes. The paper provides an overview of these structure-activity studies.
Supplementary Notes Pub. in ChemTech, p438-445 Jul 91. Prepared in cooperation with Central Piedmont Community Coll., Charlotte, NC., and Sandoz Chemicals Corp., Charlotte, NC. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Color Yes; Cancer No.
Category Codes 57Y; 99D
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 133921327
Origin NTIS
Type CAT