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OLS Field Name OLS Field Data
Main Title Assessment of Ambient UFP Health Effects: Linking Sources to Exposure and Responses in Extrapulmonary Organs.
Author G. Oberdorster ; A. Elder ; J. Finkelstein ; M. Frampton ; P. Hopke
CORP Author Rochester Univ., NY.; Clarkson Univ., Potsdam, NY.; GSF - Forschungszentrum fuer Umwelt und Gesundheit G.m.b.H., Neuherberg (Germany).; California Univ., San Diego.; LMU - Ludwig-Maximilians-Universitat, Munchen (Germany).; Environmental Protection Agency, Washington, DC.
Year Published 2011
Report Number EPA R827354
Stock Number PB2013-100299
Additional Subjects Particulates ; Health effects ; Exposure ; Respiratory system ; Age ; Air pollution ; Atherosclerotic disease ; Cardiovascular system ; Diabetes ; Diseases ; Endothelium ; Organs ; Oxidation ; Pollution sources ; Stresses ; Translocation ; Vascular system ; Ultrafine particles(UFP)
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NTIS  PB2013-100299 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/19/2013
Collation 35p
Abstract In summary, our studies show that ambient PM can have significant oxidative capacity, that UFP can induce significant effects not only in the respiratory tract but more importantly affect the vascular and cardiac system and that age and underlying disease (susceptibility factors) are critical modifying factors. Furthermore, our demonstration of their efficient translocation from deposition sites in the respiratory tract to other organs such as heart and CNS provides plausibility for UFP-induced oxidative stress in those organs. Such translocation could be particularly detrimental in susceptible individuals with dysfunctional vascular endothelium as the earliest manifestation of atherosclerotic vascular disease, such as seen in type 2 diabetes. This is presently being tested in ongoing studies.
Supplementary Notes Prepared in cooperation with Clarkson Univ., Potsdam, NY., GSF - Forschungszentrum fuer Umwelt und Gesundheit G.m.b.H., Neuherberg (Germany)., California Univ., San Diego. and LMU - Ludwig-Maximilians-Universitat, Munchen (Germany). Sponsored by Environmental Protection Agency, Washington, DC.
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PUB Date Free Form Dec 2011
Category Codes 68A; 57E; 57W
NTIS Prices PC A04
Document Type NT
Cataloging Source NTIS/MT
Control Number 120300740
Origin NTIS
Type CAT